Third son of Aaron de Sola; born at Lisbon in 1730, where he bore the name of Bartolomeu. After escaping from Portugal he went to Curaçao, where he joined his brother Isaac in West-Indian commerce. His descendants are settled in Curaçao and other parts of America. Jacob's eldest son, Elias de Sola, who died in London in 1811, was an active communal worker in Amsterdam. He was president (parnas) of the Amsterdam Talmud Torah and of the Ḥebra Biḳḳur Ḥolim, and treasurer of the Eẓ Ḥayyim.
Among other noteworthy descendants of Jacob de Sola were his grandsons, Benjamin de Sola (born in Curaçao 1818; died in New York 1882) and Elias de Sola (born in Curaçao 1826; died in Caracas 1902). Benjamin was a prominent member of the Curaçao community and was one of those who prevented changes in the ritual of the ancient Mikveh Israel Synagogue. Elias settled in Venezuela in 1856 and took a prominent part in the commercial life of Caracas and La Guayra.